A REVIEW OF METHADONE VS PHYSEPTONE

noted that rifampicin elevated the metabolism of R- and S-methadone while the CYP3A selective inhibitor troleandamycin did not have any effect on the enantiomers.If merged, monitor for QTc interval prolongation and ventricular arrhythmias. Patients with added hazard factors for QTc prolongation may be at even bigger risk. Consider therapy modificat